Synthesis and cytotoxic activity of 2, 5-disubstituted pyrimido [5, 4-c] quinoline derivatives

…, X Zhai, LJ Chen, JG Qi, B Cui, YC Gu, P Gong

文献索引：Zhang, Fan; Zhai, Xin; Chen, Li Juan; Qi, Jian Guo; Cui, Bo; Gu, Yu Cheng; Gong, Ping Chinese Chemical Letters, 2011 , vol. 22, # 11 p. 1277 - 1280

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被引用次数: 5

摘要

A series of 2, 5-disubstituted pyrimido [5, 4-c] quinoline derivatives were synthesized and their cytotoxic activity against H460, HT-29 and MDA-MB-231 cell lines was evaluated in vitro. It was found that most of the tested compounds especially compound 17, shown stronger activity to the selected three cell lines than ZM447439.