Three step procedure for the preparation of aromatic and aliphatic difluoromethyl ethers from phenols and alcohols using a chlorine/fluorine exchange methodology

WR Dolbier, F Wang, X Tang, CS Thomoson…

文献索引：Dolbier Jr., William R.; Wang, Fei; Tang, Xiaojun; Thomoson, Charles S.; Wang, Linhua Journal of Fluorine Chemistry, 2014 , vol. 160, p. 72 - 76

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被引用次数: 4

摘要

Abstract Difluoromethyl ethers are prepared from phenols in three steps via their respective formate ester derivatives. The formates are first converted to dichloromethyl ethers by treatment with PCl5. These ethers are then induced to undergo chlorine/fluorine exchange to form the respective difluoromethyl ethers. The chlorine/fluorine exchange is carried out by either a room temperature, solvolytic process using THF-5HF or Et 3 N-3HF as exchange ...