Journal of Fluorine Chemistry

Chlorodifluoromethyl aryl ketones and sulfones as difluorocarbene reagents: The substituent effect

F Wang, L Zhang, J Zheng, J Hu

文献索引：Wang, Fei; Zhang, Laijun; Zheng, Ji; Hu, Jinbo Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 521 - 528

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被引用次数: 17

摘要

Abstract We have investigated the different chlorodifluoromethyl aryl ketones 1a–1g and sulfones 2a–2h as difluorocarbene reagents for O-and N-difluoromethylations. It was found that the sulfone reagents 2 were generally more efficient in difluoromethylation than the ketone reagents 1. Furthermore, while the different substituents on ketone reagents 1 did not show a remarkable impact on the difluoromethylation reaction, the substituent effect on the ...