Enantiomerically Pure Octahydronaphthalenone and Octahydroindenone: Elaboration of the Substrate Overcame the Specificity of Yeast??Mediated Reduction

K Fuhshuku, M Tomita, T Sugai

文献索引：Fuhshuku, Ken-Ichi; Tomita, Mina; Sugai, Takeshi Advanced Synthesis and Catalysis, 2003 , vol. 345, # 6-7 p. 766 - 774

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被引用次数: 22

摘要

Abstract Substrate specificity on the reduction of bicyclic diketones with a yeast strain, Torulaspora delbrueckii IFO10921, was investigated. Although this yeast efficiently reduces the isolated carbonyl group involved in the (S)-enantiomer of Wieland–Miescher ketone with high enantioselectivity (E= 126), the introduction of a substituent on the octahydronaphthalene skeleton as well as the structural change into an octahydroindene ...