Abstract Substrate specificity on the reduction of bicyclic diketones with a yeast strain, Torulaspora delbrueckii IFO10921, was investigated. Although this yeast efficiently reduces the isolated carbonyl group involved in the (S)-enantiomer of Wieland–Miescher ketone with high enantioselectivity (E= 126), the introduction of a substituent on the octahydronaphthalene skeleton as well as the structural change into an octahydroindene ...
