前往化源商城

Journal of Enzyme Inhibition and Medicinal Chemistry 2007-02-01

Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones.

Yorishige Imamura, Rika Narumi, Hideaki Shimada

文献索引:J. Enzyme Inhib. Med. Chem. 22(1) , 105-9, (2007)

全文:HTML全文

摘要

The inhibitory effects of alkyl phenyl ketones on carbonyl reductase activity were examined in pig heart. In this study, carbonyl reductase activity was estimated as the ability to reduce 4-benzoylpyridine to S(-)-alpha-phenyl-4-pyridylmethanol in the cytosolic fraction from pig heart (pig heart cytosol). The order of their inhibitory potencies was hexanophenone > valerophenone > heptanophenone > butyrophenone > propiophenone. The inhibitory potencies of acetophenone and nonanophenone were much lower. A significant relationship was observed between Vmax/Km values for the reduction of alkyl phenyl ketones and their inhibitory potencies for carbonyl reductase activity in pig heart cytosol. Furthermore, hexanophenone was a competitive inhibitor for the enzyme activity. These results indicate that several alkyl phenyl ketones including hexanophenone inhibit carbonyl reductase activity in pig heart cytosol, by acting as substrate inhibitors.

相关化合物

结构式 名称/CAS号 全部文献
乙醇脱氢酶 结构式 乙醇脱氢酶
CAS:9028-12-0
苯庚酮 结构式 苯庚酮
CAS:1671-75-6