Journal of Natural Products 2008-10-01

Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils.

Tsung-Hsien Chou, Ih-Sheng Chen, Tsong-Long Hwang, Tai-Chi Wang, Tzong-Huei Lee, Lin-Yang Cheng, Ya-Chih Chang, Jui-Ying Cho, Jih-Jung Chen

文献索引：J. Nat. Prod. 71 , 1692-5, (2008)

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摘要

Six new phthalides, (S)-3-ethyl-7-hydroxy-6-methoxyphthalide (1), (S)-3-ethyl-7-hydroxy-5,6-dimethoxyphthalide (2), (S)-3-ethyl-5,6,7-trimethoxyphthalide (3), (R)-3-ethyl-7-hydroxy-6-methoxyphthalide (4), (Z)-3-ethylidene-7-hydroxy-6-methoxyphthalide (5), and (Z)-3-ethylidene-6,7-dimethoxyphthalide (6), have been isolated from the root of Pittosporum illicioides var. illicioides, together with seven known compounds. The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1-4 exhibited inhibition (IC50