Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents

…, GR Palnati, RP Dodda, R Sonkar, AK Khanna…

文献索引：Sashidhara, Koneni V.; Palnati, Gopala Reddy; Dodda, Ranga Prasad; Sonkar, Ravi; Khanna; Bhatia, Gitika European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 302 - 310

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被引用次数: 8

摘要

A novel series of amide based fibrates were synthesized and evaluated for antidyslipidemic activity in triton induced hyperlipidemic rats. Interestingly, the compound 13 produced striking reduction in serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). In addition, it exhibited improved lipoprotein lipase activity and found to possess moderate radical scavenging potential. The results of the above studies shows ...