Journal of Natural Products 2011-10-28

Glionitrin B, a cancer invasion inhibitory diketopiperazine produced by microbial coculture.

Hyun Bong Park, Young-Joo Kim, Jin-Soo Park, Hyun Ok Yang, Kang Ro Lee, Hak Cheol Kwon

文献索引：J. Nat. Prod. 74 , 2309-12, (2011)

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摘要

A new diketopiperazine, glionitrin B (1), was produced using a microbial coculture of the fungus Aspergillus fumigatus KMC-901 and the bacterium Sphingomonas sp. KMK-001 that were isolated from acidic coal mine drainage. The structure of 1 was determined to be (3S,10aS)-dithiomethylglionitrin A. This structure was determined by the analyses of extensive NMR data and the circular dichroism spectra of the natural product and a semisynthetic compound derived from glionitrin A. In contrast to glionitrin A (2), glionitrin B (1) is not cytotoxic against the human prostate cancer cell line DU145. However, compound 1 caused suppression of DU145 cell invasion, producing 46% inhibition at 60 μM.