Tetrahedron

Synthesis of 5′-polyarene-tethered oligo-DNAs and the thermal stability and spectroscopic properties of their duplexes and triplexes

N Puri, E Zamaratski, C Sund, J Chattopadhyaya

文献索引：Puri, Nitin; Zamaratski, Edouard; Sund, Christian; Chattopadhyaya, Jyoti Tetrahedron, 1997 , vol. 53, # 30 p. 10409 - 10432

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被引用次数: 28

摘要

Eleven different planar hydroxy alkylated polyarenes 1–11 with different geometry, bulk and electronic characteristics were synthesised, and used for tethering to the 5′-phosphate of a 9-mer and a 18-mer DNA sequences through solid-phase synthesis. The 5′-polyarene- tethered 9-mers 30–40 were tested for their ability to form stable duplexes with four complementary target DNA-strands 25–28 of different length. The 5′-polyarene-tethered ...