Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover)

…, MI Churchwell, G Gamboa da Costa…

文献索引：Roberts, Dean W.; Doerge, Daniel R.; Churchwell, Mona I.; Da Costa, Goncalo Gamboa; Marques, M. Matilde; Tolleson, William H. Journal of Agricultural and Food Chemistry, 2004 , vol. 52, # 21 p. 6623 - 6632

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被引用次数: 55

摘要

Biochanin A and formononetin are the predominant isoflavones in red clover. In a previous study (J. Agric. Food Chem. 2002, 50, 4783-4790), it was demonstrated that human liver microsomes converted biochanin A and formononetin to genistein and daidzein. This paper now shows CYP1B1-catalyzed O-demethylation of biochanin A and formononetin to produce genistein and daidzein, respectively, which inhibit CYP1B1. Recombinant human ...