Structural requirement of isoflavonones for the inhibitory activity of interleukin-5

…, JH Lee, JH Ju, MK Kim, SH Lee, JC Ryu, Y Kim

文献索引：Jung, Sang-Hun; Cho, Soo-Hyun; Hung Dang, The; Lee, Jee-Hyun; Ju, Jung-Hun; Kim, Mi-Kyung; Lee, Seung-Ho; Ryu, Jae-Chun; Kim, Youngsoo European Journal of Medicinal Chemistry, 2003 , vol. 38, # 5 p. 537 - 545

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被引用次数: 47

摘要

Sophoricoside isolated from Sophora japonica is a glycoside of isoflavonone as an inhibitor of interleukin (IL)-5. To identify structural requirements of this isoflavonone for its inhibitory activity against IL-5, isoflavonones, isoflavanones, and their glycosides were prepared and their inhibitory activity was tested against IL-5. Among them, 5-benzyloxy-3-(4- hydroxyphenyl) chromen-4-one (4b, 87.9% inhibition at 50 μM, IC50= 15.3 μM) shows the ...