Organic letters

Continuous flow coupling and decarboxylation reactions promoted by copper tubing

Y Zhang, TF Jamison, S Patel, N Mainolfi

文献索引：Zhang, Yun; Jamison, Timothy F.; Patel, Sejal; Mainolfi, Nello Organic Letters, 2011 , vol. 13, # 2 p. 280 - 283

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被引用次数: 56

摘要

A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (eg, Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.