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Tetrahedron Letters

One-pot esterification and Ritter reaction: chemo-and regioselectivity from tert-butyl methyl ether

P Dawar, MB Raju, RA Ramakrishna

文献索引:Dawar, Pankaj; Bhagavan Raju; Ramakrishna, Ramesha A. Tetrahedron Letters, 2011 , vol. 52, # 33 p. 4262 - 4265

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被引用次数: 9

摘要

tert-Butyl methyl ether (TBME) has been effectively used as a reagent for esterification of carboxylic acids. By varying amounts of sulfuric acid, a remarkable regioselectivity in esterification has been demonstrated. Additionally, under the present reaction conditions, one-pot esterification and Ritter reaction are achieved in almost quantitative yield.

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