Pyridazines. 63. Novel thiosemicarbazones derived from formyl-and acyldiazines: synthesis, effects on cell proliferation, and synergism with antiviral agents

…, G Heinisch, W Holzer, B Rosenwirth

文献索引：Easmon; Heinisch; Holzer; Rosenwirth Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3288 - 3296

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被引用次数: 64

摘要

The synthesis of a series of novel thiosemicarbazones (TSC's) derived from various alkyl diazinyl (3-pyridazinyl, 4-pyrimidinyl, 2-pyrazinyl) ketones and 3-pyridazinecarbaldehyde and their evaluation against herpes simplex virus (HSV) and human immunodeficiency virus (HIV) as well as the determination of their cytotoxicity are described. In addition, the effects of combination of such TSC's with the well-known antiviral drugs acyclovir (ACV) and 3'- ...