Pyridazines. 63. Novel thiosemicarbazones derived from formyl-and acyldiazines: synthesis, effects on cell proliferation, and synergism with antiviral agents

…, G Heinisch, W Holzer, B Rosenwirth

Index: Easmon; Heinisch; Holzer; Rosenwirth Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3288 - 3296

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Citation Number: 64

Abstract

The synthesis of a series of novel thiosemicarbazones (TSC's) derived from various alkyl diazinyl (3-pyridazinyl, 4-pyrimidinyl, 2-pyrazinyl) ketones and 3-pyridazinecarbaldehyde and their evaluation against herpes simplex virus (HSV) and human immunodeficiency virus (HIV) as well as the determination of their cytotoxicity are described. In addition, the effects of combination of such TSC's with the well-known antiviral drugs acyclovir (ACV) and 3'- ...