Bioorganic & Medicinal Chemistry Letters 2008-08-15

Selective inhibitory effects of hybrid liposomes on the growth of HIV type 1-infected cells in vitro.

Ryuichi Ueoka, Yuji Komizu, Yoko Matsumoto, Yu Zhong, Ritsuko Tanaka, Naoki Yamamoto, Ryuichi Ueoka, Yuji Komizu, Yoko Matsumoto, Yu Zhong, Ritsuko Tanaka, Naoki Yamamoto

文献索引：Bioorg. Med. Chem. Lett. 18 , 4578-80, (2008)

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摘要

A good correlation between fifty-percent inhibitory concentration (IC(50)) of hybrid liposomes (HL) composed of dimyristoylphosphatidylcholine and polyoxyethylene(n) dodecyl ether on the growth of MOLT-4/IIIB cells (MOLT-4 cells chronically infected with human immunodeficiency virus (HIV)) and the membrane fluidity of HL was obtained. Furthermore, the huge enhancement of virus production was observed in the latently HIV-infected (J(22)-HL-60) cells after the treatment with HL.