Bioorganic & Medicinal Chemistry Letters 2008-08-15

Selective inhibitory effects of hybrid liposomes on the growth of HIV type 1-infected cells in vitro.

Ryuichi Ueoka, Yuji Komizu, Yoko Matsumoto, Yu Zhong, Ritsuko Tanaka, Naoki Yamamoto, Ryuichi Ueoka, Yuji Komizu, Yoko Matsumoto, Yu Zhong, Ritsuko Tanaka, Naoki Yamamoto

Index: Bioorg. Med. Chem. Lett. 18 , 4578-80, (2008)

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Abstract

A good correlation between fifty-percent inhibitory concentration (IC(50)) of hybrid liposomes (HL) composed of dimyristoylphosphatidylcholine and polyoxyethylene(n) dodecyl ether on the growth of MOLT-4/IIIB cells (MOLT-4 cells chronically infected with human immunodeficiency virus (HIV)) and the membrane fluidity of HL was obtained. Furthermore, the huge enhancement of virus production was observed in the latently HIV-infected (J(22)-HL-60) cells after the treatment with HL.