An improved approach to N-substituted maleimides and phthalimides by microwave-promoted Mitsunobu reaction

CD Mayer, M Kehrel, F Bracher

文献索引：Mayer, Christoph D.; Kehrel, Marcus; Bracher, Franz Organic Preparations and Procedures International, 2008 , vol. 40, # 6 p. 574 - 574

全文：HTML全文

被引用次数: 7

摘要

Maleimide derivatives are of high interest as substrates in biological applications. Due to its Michael-accepting ability the maleimido group is able to react with nucleophilic groups, eg thiol groups in biomolecules. I Therefore substrates containing terminal maleimido functionality can undergo covalent coupling to cysteine residues of enzymes or other proteins? Bifunctional derivatives with a maleimido group attached to one end and a ...