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Synthetic Communications

Syntheses of some N-alkylmaleimides

ZY Wang

文献索引:Wang, Z. Y. Synthetic Communications, 1990 , vol. 20, # 11 p. 1607 - 1610

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被引用次数: 26

摘要

The imidization of N-substituted rnaleamic acids in the presence of a dehydrating agent, such as acetic anhydride, to yield the N-substituted maleimides is a well-known classic reaction'. However, the reaction requires a large excess of acetic anhydride as both reagent and solvent and sodium acetate as a base, and is limited only to aryl substituents. In the case of primary alkyl groups, low to moderate yields (15- 60%) of N-alkyl maleimides were obtainedZ3. For ...