Organic & biomolecular chemistry

Regio-and stereoselective synthesis of spirooxindole 1′-nitro pyrrolizidines with five concurrent stereocenters under aqueous medium and their bioprospection using …

CEP Galvis, VV Kouznetsov

文献索引：Puerto Galvis, Carlos E.; Kouznetsov, Vladimir V. Organic and Biomolecular Chemistry, 2013 , vol. 11, # 42 p. 7372 - 7386

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被引用次数: 22

摘要

A highly regio-and stereoselective method has been developed and expanded for the synthesis of a 20-membered library of spirooxindole 1′-nitro pyrrolizidines via 1, 3-dipolar cycloaddition of azomethine ylides, generated in situ by a decarboxylative route from a common set of diverse isatins and L-proline derivatives, with substituted β-nitrostyrenes under aqueous medium. Among various reaction conditions, water proved to be ...