Inhibition of thioredoxin reductase by a novel series of bis-1, 2-benzisoselenazol-3 (2H)-ones: Organoselenium compounds for cancer therapy

…, K Xiong, Y Ge, H Jin, G Zhang, M Hong, Y Tian…

文献索引：He, Jie; Li, Dongdong; Xiong, Kun; Ge, Yongjie; Jin, Hongwei; Zhang, Guozhou; Hong, Mengshi; Tian, Yongliang; Yin, Jin; Zeng, Huihui Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 12 p. 3816 - 3827

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被引用次数: 30

摘要

Thioredoxin reductase (TrxR) is critical for cellular redox regulation and is involved in tumor proliferation, apoptosis and metastasis. Its C-terminal redox-active center contains a cysteine (Cys497) and a unique selenocysteine (Sec498), which are exposed to solvent and easily accessible. Thus, it is becoming an important target for anticancer drugs. Selective inhibition of TrxR by 1, 2-(bis-1, 2-benzisoselenazol-3 (2H)-one) ethane (4a) prevents ...