前往化源商城

Biomaterials 2015-03-01

Cell selective chitosan microparticles as injectable cell carriers for tissue regeneration.

C A Custódio, M T Cerqueira, A P Marques, R L Reis, J F Mano

文献索引:Biomaterials 43 , 23-31, (2015)

全文:HTML全文

摘要

The detection, isolation and sorting of cells holds an important role in cell therapy and regenerative medicine. Also, injectable systems have been explored for tissue regeneration in vivo, because it allows repairing complex shaped tissue defects through minimally invasive surgical procedures. Here we report the development of chitosan microparticles with a size of 115.8 μm able to capture and expand a specific cell type that can also be regarded as an injectable biomaterial. Monoclonal antibodies against cell surface antigens specific to endothelial cells and stem cells were immobilized on the surface of the microparticles. Experimental results showed that particles bioconjugated with specific antibodies provide suitable surfaces to capture a target cell type and subsequent expansion of the captured cells. Primarily designed for an application in tissue engineering, three main challenges are accomplished with the herein presented microparticles: separation, scale-up expansion of specific cell type and successful use as an injectable system to form small tissue constructs in situ. Copyright © 2014 Elsevier Ltd. All rights reserved.

相关化合物

结构式 名称/CAS号 全部文献
乙醇 结构式 乙醇
CAS:64-17-5
甲醛 结构式 甲醛
CAS:50-00-0
冰醋酸 结构式 冰醋酸
CAS:64-19-7
阿非科林 结构式 阿非科林
CAS:38966-21-1
碳酸氢钠 结构式 碳酸氢钠
CAS:144-55-8
1-(3,4-亚甲二氧基苯基)-2-丁胺 结构式 1-(3,4-亚甲二氧基苯基)-2-丁胺
CAS:42542-07-4
碳酸氢钾 结构式 碳酸氢钾
CAS:298-14-6
氯化铵 结构式 氯化铵
CAS:12125-02-9
乙二胺四乙酸 结构式 乙二胺四乙酸
CAS:60-00-4
雄诺龙 结构式 雄诺龙
CAS:521-18-6