Diarylspiro [2.4] heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships

HC Huang, JJ Li, DJ Garland…

文献索引：Journal of Medicinal Chemistry, , vol. 39, # 1 p. 253 - 266

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被引用次数: 59

摘要

... Journal of Medicinal Chemistry. ... 3,4 Because of these problems, the pharmaceutical industry has been pursuing opportunities to develop drugs that possess antiinflammatory activity without the toxic side effects associated with known NSAIDs. ...