Synthesis of Rofecoxib,(MK 0966, Vioxx® 4-(4′-Methylsulfonylphenyl)-3-Phenyl-2 (5H)-Furanone), a Selective and Orally Active Inhibitor of Cyclooxygenase-2

M Thérien, JY Gauthier, Y Leblanc, S Léger…

文献索引：Synthesis, , # 12 p. 1778 - 1779

全文：HTML全文

被引用次数: 19

摘要

... Received 26 January 2001 Publication Date: 12 August 2004 (online). ... magnesium mediated carbometallation of phenylpropargyl alcohol, and applied this methodology to synthesize Rofecoxib. ... In conclusion, a highly efficient synthesis of the COX-2 inhibitor Rofecoxib has been ...