Nanoscale 2015-08-07

An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates.

Lei Zhang, Yecheng Li, Zexun Jin, Jimmy C Yu, King Ming Chan

文献索引：Nanoscale 7 , 12614-24, (2015)

全文：HTML全文

摘要

Nanomaterials for effective drug delivery require zero pre-release and on-demand release of therapeutic drugs. In this work we demonstrate a novel drug delivery system composed of a mesoporous silica platform conjugated to CuS nanoparticles with two complementary DNA sequences. CuS nanoparticles act as both gatekeepers preventing pre-release of drugs and photothermal agents for effective killing of cancer cells. This system exhibits temperature and NIR-responsive DOX release, with an additional accelerated release rate with GSH treatment. Therefore, it can act as an effective anticancer drug delivery carrier with triggered drug release and efficient anti-cancer effect in vitro after NIR irradiation.