前往化源商城

European Journal of Pharmaceutical Sciences 2015-10-12

Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders.

Li Qu, Qi Tony Zhou, John A Denman, Peter J Stewart, Karen P Hapgood, David A V Morton

文献索引:Eur. J. Pharm. Sci. 78 , 264-72, (2015)

全文:HTML全文

摘要

This study investigates the effects of a variety of coating materials on the flowability and dissolution of dry-coated cohesive ibuprofen powders, with the ultimate aim to use these in oral dosage forms. A mechanofusion approach was employed to apply a 1% (w/w) dry coating onto ibuprofen powder with coating materials including magnesium stearate (MgSt), L-leucine, sodium stearyl fumarate (SSF) and silica-R972. No significant difference in particle size or shape was measured following mechanofusion with any material. Powder flow behaviours characterised by the Freeman FT4 system indicated coatings of MgSt, L-leucine and silica-R972 produced a notable surface modification and substantially improved flow compared to the unprocessed and SSF-mechanofused powders. ToF-SIMS provided a qualitative measure of coating extent, and indicated a near-complete layer on the drug particle surface after dry coating with MgSt or silica-R972. Of particular note, the dissolution rates of all mechanofused powders were enhanced even with a coating of a highly hydrophobic material such as magnesium stearate. This surprising increase in dissolution rate of the mechanofused powders was attributed to the lower cohesion and the reduced agglomeration after mechanical coating.Copyright © 2015 Elsevier B.V. All rights reserved.

相关化合物

结构式 名称/CAS号 全部文献
氢氧化钠 结构式 氢氧化钠
CAS:1310-73-2
十二烷基硫酸钠 结构式 十二烷基硫酸钠
CAS:151-21-3
3-乙基-2,4-戊烷二酮 结构式 3-乙基-2,4-戊烷二酮
CAS:1540-34-7
硬脂酸镁 结构式 硬脂酸镁
CAS:557-04-0
L-亮氨酸 结构式 L-亮氨酸
CAS:61-90-5
磷酸二氢钾 结构式 磷酸二氢钾
CAS:7778-77-0
布洛芬 结构式 布洛芬
CAS:15687-27-1