The International Journal of Biochemistry & Cell Biology 2015-04-01

Protein tyrosine phosphatase 1B (PTP1B) is involved in the defective erythropoietic function of carbamylated erythropoietin.

María Eugenia Chamorro, Romina Eugenia Maltaneri, Daniela Cecilia Vittori, Alcira Beatriz Nesse

文献索引：Int. J. Biochem. Cell Biol. 61 , 63-71, (2015)

全文：HTML全文

摘要

• Epo induced prolonged phosphorylation of proliferation signals in UT-7 cells. • cEpo induced only transient phosphorylation of proliferative pathways. • PTP1B activity was significantly increased in cultures with cEpo. • PTP1B colocalized with both subunits of the heterodimeric receptor used by cEpo. • Phosphatases are involved in the inability of cEpo to act as an erythroid growth factor.