Carba??acyclonucleoside antiherpetic agents

J Hannah, RL Tolman, JD Karkas…

文献索引：Hannah; Tolman; Karkas; Liou; Perry; Field Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 5 p. 1261 - 1271

被引用次数: 32

摘要

Abstract Ganciclovir 2 and 2′-carba-ganciclovir 5a are anti-viral agents differing structurally only in the replacement of an oxygen by a methylene group and yet expressing their biological properties along mechanistically independent pathways. Methoxy, hydroxy and fluoro derivatives of 2′-carba-ganciclovir were prepared to examine the effect of re- introducing a binding site close to that in the original oxa side chain. The cyclic phosphate ...

A direct approach to the synthesis of famciclovir and pencic...

[Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994]

Practical syntheses of penciclovir and famciclovir from N2-a...

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Novel radiosynthesis of PET HSV-tk gene reporter probes [18 ...

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