Tetrahedron

Practical syntheses of penciclovir and famciclovir from N2-acetyl-7-benzylguanine

…, K Yamashita, Y Suzuki, T Hijiya, T Kashiwagi, K Izawa

文献索引：Torii, Takayoshi; Shiragami, Hiroshi; Yamashita, Keizo; Suzuki, Yumiko; Hijiya, Toyoto; Kashiwagi, Tatsuki; Izawa, Kunisuke Tetrahedron, 2006 , vol. 62, # 24 p. 5709 - 5716

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被引用次数: 9

摘要

We have established practical methods for the synthesis of penciclovir (PCV) and famciclovir (FCV) from readily available guanosine via N2-acetyl-7-benzylguanine. The alkylation of N2- acetyl-7-benzylguanine proceeded selectively at the N9 position to give the desired alkylated product in good yield in salt form. After conventional catalytic hydrogenolysis of the benzyl group and hydrolysis of the resulting acetate, pure PCV was obtained without the ...