Synthesis of (–)??Oseltamivir by Using a Microreactor in the Curtius Rearrangement

H Ishikawa, BP Bondzic…

文献索引：Ishikawa, Hayato; Bondzic, Bojan P.; Hayashi, Yujiro European Journal of Organic Chemistry, 2011 , # 30 p. 6020 - 6031

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被引用次数: 17

摘要

Abstract A microflow reaction of the Curtius rearrangement by using trimethylsilyl azide as an azide source, followed by trapping of the generated isocyanate with a nucleophile was established, which is safe, inexpensive, and suitable for large-scale synthesis. By this flow reaction in the Curtius rearrangement and recrystallization of the late-stage acetamide intermediate the third-generation synthesis of (–)-Oseltamivir has been established, which ...