Synthesis

Monosubstituted malononitriles: Efficient one-pot reductive alkylations of malononitrile with aromatic aldehydes

F Tayyari, DE Wood, PE Fanwick, RE Sammelson

文献索引：Tayyari, Fariba; Wood, Dwight E.; Fanwick, Phillip E.; Sammelson, Robert E. Synthesis, 2008 , # 2 p. 279 - 285

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被引用次数: 22

摘要

Abstract A powerful new one-pot method has been developed for the reductive alkylation of malononitrile with aromatic aldehydes. This new procedure has vastly improved the yield and efficiency of the process, and increased the scope of the aromatic aldehydes. Incorporating water as the catalyst in ethanol for the condensation step allows stoichiometric amounts of malononitrile and aldehyde to be employed. The reduction step takes place ...