Tetrahedron Letters

Highly efficient three-component (aldehyde–alkyne–amine) coupling reactions catalyzed by a reusable PS-supported NHC–Ag (I) under solvent-free reaction …

P Li, L Wang, Y Zhang, M Wang

文献索引：Li, Pinhua; Wang, Lei; Zhang, Yicheng; Wang, Min Tetrahedron Letters, 2008 , vol. 49, # 47 p. 6650 - 6654

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被引用次数: 81

摘要

The development of a highly efficient, polystyrene-supported NHC–Ag (I) catalyst for the three-component coupling reactions of aldehydes, alkynes, and amines (A3-coupling) was described. In the presence of PS–NHC–Ag (I)(2mol%), the A3-reactions were carried out at room temperature under solvent-free reaction conditions and the corresponding propargylamines were generated in good to excellent yields. Furthermore, the catalyst ...