Conformation and activity of tetrahydrofuran lignans and analogs as specific platelet-activating-factor antagonists

T Biftu, NF Gamble, T Doebber, SB Hwang…

文献索引：Biftu; Gamble; Doebber; Hwang; Shen; Snyder; Springer; Stevenson Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1917 - 1921

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被引用次数: 66

摘要

4 5 6 products known as lignans. These tetrahydrofuran lignans may exist in six stereoisomeric forms 1-6 (Chart I). These are tetrahydrofuroguaicin B dimethyl ether (1) veraguensin (2), 1618 saucerneol (3), 21 galbelgin (4), 18-20 5 (not reported previously in the literature), and galgravin (6). l* 15 Synthetic (f)-veraguensin'* obtained from the author's previous academic work was found to inhibit PAF binding to platelets. Encouraged by this ...