Synthesis and trypanocidal activity of 1, 4-bis-(3, 4, 5-trimethoxy-phenyl)-1, 4-butanediol and 1, 4-bis-(3, 4-dimethoxyphenyl)-1, 4-butanediol

LSC Bernardes, MJ Kato, S Albuquerque…

文献索引：Bernardes, Lilian Sibelle Campos; Kato, Massuo Jorge; Albuquerque, Sergio; Carvalho, Ivone Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 21 p. 7075 - 7082

全文：HTML全文

被引用次数: 30

摘要

Chagas' disease is endemic in Central and South American countries. Specific chemotherapy with nifurtimox or benznidazole has been recommended for treatment of recent infection but they have limited efficacy. The natural products veraguensin (1) and grandisin (2) have shown potent in vitro activity against trypomastigote parasite (Y strain) with IC50 2.3 μM (1) and 3.7 μM (2). We report herein the synthesis and in vitro ...