Carbon??14 radiosynthesis of the benzofuran derivative and β??amyloid plaque neuroimaging positron emission tomography radioligand AZD4694

J Sandell

文献索引：Sandell, Johan Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 6 p. 321 - 324

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摘要

In support of a metabolite study, the b-amyloid plaque neuroimaging positron-emission tomography radioligand AZD4694 was labeled with carbon-14 in 10 radiosynthetic steps starting from radiolabeled carbon dioxide.[14C] AZD4694 was labeled in the benzofuran heterocycle with a specific activity of 2.1 GBq/mmol and with a radiochemical purity of> 99%. The described synthesis constitutes a general method to carbon-14-labeled substituted ...