In support of a metabolite study, the b-amyloid plaque neuroimaging positron-emission tomography radioligand AZD4694 was labeled with carbon-14 in 10 radiosynthetic steps starting from radiolabeled carbon dioxide.[14C] AZD4694 was labeled in the benzofuran heterocycle with a specific activity of 2.1 GBq/mmol and with a radiochemical purity of> 99%. The described synthesis constitutes a general method to carbon-14-labeled substituted ...
