Journal of the American Chemical Society

Model studies on the mechanism of biotin dependent carboxylations

H Kohn

文献索引：Kohn,H. Journal of the American Chemical Society, 1976 , vol. 98, p. 3690 - 3694

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被引用次数: 22

摘要

Abstract: The syntheses of both N-carbomethoxy-2-phenacylthioimidazoline(8) and its N- methyl salt, N-methyl-N-carbome-thoxy-2-phenacylthioimidazolinium fluoroborate (S), are described. Both substrates can be considered potential models for carboxy-biotin complexes. The reactivity of each of these substrates toward base has been evaluated. Treatment of 8 with 1 equiv of either sodium methoxide or sodium hydride yielded the ...