Phenacylthioimidazolines and 3-aryl-5, 6-dihydroimidazo [2, 1-b] thiazoles with antidepressant activity

CJ Sharpe, RS Shadbolt, A Ashford…

文献索引：Sharpe,C.J. et al. Journal of Medicinal Chemistry, 1971 , vol. 14, # 10 p. 977 - 982

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被引用次数: 48

摘要

The reported antidepressant activity of 2-(3, 4-dich1orophenoxymethyl) imidazoline'and an interest in imidazo [2, 1-b] thiazoles, prompted us to prepare 2-(3, 4-dichlorophenacylthio) imidazoline which proved to be exceptionally potent (ED50= 0.5 mg/kg) in the reserpine hypothermia test in mice. The effects on antireserpine activity of substitution in the Ph ring of phenacylthioimidazoline and the activity of the corresponding 5, 6-dihydroimidazo [2, 1-b] ...