Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease

I Lagoja, C Pannecouque, G Griffioen, S Wera…

文献索引：Lagoja, Irene; Pannecouque, Christophe; Griffioen, Gerard; Wera, Stefaan; Rojasdelaparra, Veronica Maria; Van Aerschot, Arthur European Journal of Pharmaceutical Sciences, 2011 , vol. 43, # 5 p. 386 - 392

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被引用次数: 18

摘要

Abstract A novel series of 2-aminothiazoles with strong protection in an Alzheimer's disease (AD) model comprising tau-induced neuronal toxicity is disclosed. These derivatives can be synthesized in one-pot and a small SAR of the substitution within these series afforded several compounds that counteracted tau-induced cell toxicity at nanomolar concentrations. These congeners therefore have strong potential as possible treatment for Alzheimer's ...