Journal of the American Chemical Society

Catalytic cross-coupling of alkylzinc halides with α-chloroketones

CF Malosh, JM Ready

文献索引：Malosh, Chrysa F.; Ready, Joseph M. Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10240 - 10241

全文：HTML全文

被引用次数: 57

摘要

The cross-coupling of alkylzinc halides with α-chloroketones catalyzed by Cu (acac) 2 is described. Using this method, primary and secondary alkyl groups are introduced adjacent to a ketone carbonyl under mild reaction conditions and in good yield. Cyclic, acyclic, aromatic, and aliphatic α-chloroketones are suitable substrates. Optically active α- chloroketones are converted to optically active products. The reaction was found to ...