Chemical Communications

Fluorination reactions in microreactors

T Gustafsson, R Gilmour, PH Seeberger

文献索引：Gustafsson, Tomas; Gilmour, Ryan; Seeberger, Peter H. Chemical Communications, 2008 , # 26 p. 3022 - 3024

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被引用次数: 31

摘要

In order to establish general deoxyfluorination conditions, exploratory reactions were performed in toluene, dichloromethane and tetrahydrofuran. Dichloromethane was quickly identified as being the solvent of choice. Furthermore, the incorporation of a 75 psi HPLC back pressure regulator allowed the solvent to be super-heated to 70 °C resulting in shortened reaction times. 10 For economic reasons it was deemed prudent to use exactly 1 equivalent of DAST in the ...