In order to establish general deoxyfluorination conditions, exploratory reactions were performed in toluene, dichloromethane and tetrahydrofuran. Dichloromethane was quickly identified as being the solvent of choice. Furthermore, the incorporation of a 75 psi HPLC back pressure regulator allowed the solvent to be super-heated to 70 °C resulting in shortened reaction times. 10 For economic reasons it was deemed prudent to use exactly 1 equivalent of DAST in the ...
