Alternative synthesis of tadalafil: PDE5 inhibitor

…, PP Reddy, A Bhattacharya, R Bandichhor

文献索引：Anumula, Raghupathi Reddy; Madivada, Lokeswara Rao; Gilla, Goverdhan; Raju, V. V. N. K. Prasad; Kagga, Mukkanti; Reddy, Padi Pratap; Bhattacharya, Apurba; Bandichhor, Rakeshwar Synthetic Communications, 2008 , vol. 38, # 23 p. 4265 - 4271

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被引用次数: 2

摘要

Abstract Two-step alternative synthesis of tadalafil (1) is described. The synthesis features Pictet–Spengeler type reaction and DCC (N, N′-dicyclohexylcarbodiimide)/HOBt (N- hydroxybenzotriazole)–mediated double amidation employing sarcosine ethyl ester hydrochloride.