Synlett

Two concise syntheses of cialis via the N-acyliminium Pictet-Spengler reaction

JD Revell, N Srinivasan, A Ganesan

文献索引：Revell, Jefferson D.; Srinivasan, Natarajan; Ganesan Synlett, 2004 , # 8 p. 1428 - 1430

全文：HTML全文

被引用次数: 19

摘要

Inhibition of the cGMP specific Type V phosphodiesterase (PDE5) was originally investigated as a target for antihypertensive and antianginal therapy. With the serendipitous discovery of the effects of the PDE5 inhibitor sildenafil, such compounds have become a powerful means [1] of treating erectile dysfunction. Besides sildenafil (Viagra, Pfizer), two other PDE5 inhibitors, vardenafil (Levitra, Bayer/GlaxoSmithKline) and tadalafil, (Cialis, Icos/Lilly) have recently gained ...