Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers

NJ Lawrence, D Rennison, M Woo, AT McGown…

文献索引：Lawrence, Nicholas J.; Rennison, David; Woo, Meiki; McGown, Alan T.; Hadfield, John A. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 1 p. 51 - 54

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被引用次数: 58

摘要

A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3′, 4′, 5′- trimethoxyphenoxymethyl) phenol was the most active (IC50, K562 20nM) and caused significant G2/M cell cycle arrest.