Synthesis, structure–activity relationships, and mechanism of action of anti-HIV-1 lamellarin α 20-sulfate analogues

…, N Yamamoto, T Fukuda, F Ishibashi, M Iwao

文献索引：Kamiyama, Haruka; Kubo, Yoshinao; Sato, Hironori; Yamamoto, Naoki; Fukuda, Tsutomu; Ishibashi, Fumito; Iwao, Masatomo Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7541 - 7550

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被引用次数: 16

摘要

Lamellarin α and six different types of lamellarin α 20-sulfate analogues were synthesized and their structure–activity relationships were investigated using a single round HIV-1 vector infection assay. All lamellarin sulfates having pentacyclic lamellarin core exhibited anti-HIV- 1 activity at a 10μM concentration range regardless of the number and position of the sulfate group. On the other hand, non-sulfated lamellarin α and ring-opened lamellarin sulfate ...