The discovery and development of a safe, practical synthesis of ABT-869

AW Kruger, MJ Rozema, A Chu-Kung…

文献索引：Organic Process Research and Development, , vol. 13, # 6 p. 1419 - 1425

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被引用次数: 16

摘要

... This article is part of the Safety of Chemical Processes 09 special issue ... However, a safety evaluation found that the NMP process was not safe for scale-up ... variety of inorganic bases raised the T ONSET for exothermic decomposition to >300 °C. In contrast, organic bases showed ...