Design, synthesis and evaluation of racemic 1-(4-hydroxyphenyl)-2-[3-(substituted phenoxy)-2-hydroxy-1-propyl] amino-1-propanol hydrochlorides as novel uterine …

CL Viswanathan, MM Kodgule…

文献索引：Viswanathan; Kodgule; Chaudhari Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 15 p. 3532 - 3535

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被引用次数: 6

摘要

Novel 1-(4-hydroxyphenyl)-2-[3-(substituted phenoxy)-2-hydroxy-1-propyl] amino-1- propanol hydrochlorides were designed based on the pharmacophore for potent uterine relaxant activity and by utilizing the principles of structural hybridization. The designed molecules were synthesized as racemates by a novel route and were evaluated for uterine relaxant activity in vitro on isolated rat uterus and in vivo in pregnant rats. Their cAMP- ...