5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity

K Watanabe, Y Morinaka, Y Hayashi, M Shinoda…

文献索引：Watanabe, Kazutoshi; Morinaka, Yasuhiro; Hayashi, Yoshio; Shinoda, Masaki; Nishi, Hiroyoshi; Fukushima, Nobuko; Watanabe, Toshiaki; Ishibashi, Akira; Yuki, Satoshi; Tanaka, Masahiko Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 4 p. 1478 - 1483

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被引用次数: 18

摘要

A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation.